The Effects of Protein Supplementation With or Without Urolithin A During Single-leg Immobilization

Exclusion Criteria

• •1. Subject has any concurrent medical, orthopedic, or psychiatric requirements that, in the opinion of the investigators, would compromise their ability to comply with the study requirements
• •2. Clinically significant abnormal laboratory results at screening
• •3. Participation in a clinical research trial within 30 days before randomization
• •4. Allergy or sensitivity to study ingredients
• •5. Individuals who are cognitively impaired and/or who are unable to give informed consent
• •6. Any other condition that, in the opinion of the investigators, may adversely affect the subject's ability to complete the study or its measures or may pose a significant risk to the subject
• •7. Any cachexia-related condition or any genetic muscle diseases or disorders
• •8. Current gastrointestinal condition that could interfere with the study (e.g., IBS/IBD \[irritable bowel syndrome/inflammatory bowel disease\], diarrhea, acid reflux disease, dysphagia, etc.)
• •9. Excessive alcohol consumption (\>21 units/week) and/or a smoker (cigarettes or vaping)
• •10. Concomitant use of corticosteroids, antibiotics, any anabolic steroid, creatine, whey protein supplements, casein, branched-chain amino acids (BCAAs) or any other NHP \[Natural Health Product\], medication or supplement used for muscle strengthening/building within 45 days prior to screening
• •11. Contraindications to an MRI scan (metal implants, metal-based ink tattoo)