Effect of Metformin on Patients With Polycystic Ovary Syndrome

Exclusion Criteria

• •1. Individuals who suffering from other diseases that may cause hyperandrogenism and ovulation abnormalities.
• •2. Individuals who are during pregnant, lactation or menopause.
• •3. Individuals who currently receiving weight-loss drugs or surgery or within the past 2 months.
• •4. Individuals who take niacin, nicotinamide, or other vitamin B3-related supplementation currently or within the past 2 months.
• •5. Individuals who need regular medication to treat chronic diseases such as diabetes, hypertension, gout, hyperuricemia, etc.
• •6. Use of medications that affect hormone levels, appetite, carbohydrate absorption, and metabolism within the past 2 months.
• •7. Individuals with severe liver diseases or kidney disease that are ineligible to participate in the study.
• •8. A medical history of severe cardiovascular and cerebrovascular diseases.
• •9. Individuals who currently suffer from severe gastrointestinal diseases or undergo gastrointestinal resection that may affect nutrient absorption.
• •10. Individuals who drink more than 15g of alcohol per day or have a smoking habit.
• •11. Individuals who need drug treatment for any mental illness such as epilepsy and depression.
• •12. Cancer patients.
• •13. Individuals who suffer from infectious diseases such as hepatitis B, active tuberculosis, AIDS, etc.