Age

18–90

Sex

ALL

Healthy volunteers

Not accepted

Patients with chronic obstructive pulmonary disease who meet the GOLD diagnostic criteria
FEV1 ≤ 45% pred and FEV1/FVC\<70%
TLC\>100% pred and RV\>175% pred
CAT≥18
\>50% of emphysema destruction
Smoking prohibition\>6 months
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PaCO2\>8.0 kPa, or PaO2\<6.0 kPa
6-minute walking test\<160m
Obvious chronic bronchitis, bronchiectasis or other infectious lung diseases
Three hospitalizations due to pulmonary infection in the past 12 months before the baseline assessment
Previous lobectomy, LVRS or lung transplantation
LVEF\<45% and or RVSP\>50mmHg
Anticoagulant therapy that cannot be stopped before surgery
The patient has obvious immune deficiency
Participated in other lung drug studies within 30 days before this study
Pulmonary nodules requiring intervention
Any disease or condition that interferes with the completion of the initial or subsequent assessment

Evaluation of the Effectiveness of the Self-developed Pulmonary Lobar Ventilation Detector