Pre-Habilitation with Mindfulness and Exercise for Patients Undergoing Radical Cystectomy (PRIMER Trial)

Inclusion Criteria

• •Provision of signed and dated informed consent form
• •Stated willingness to comply with all study procedures and availability for the duration of the study
• •Male or female, aged ≥18 years of age
• •Good surgical candidate determined by treating surgeon
• •Histologically documented muscle invasive urothelial carcinoma of the bladder, high-risk non-muscle invasive bladder cancer, non-muscle invasive bladder cancer refractory to BCG, cisplatin ineligible muscle invasive bladder cancer receiving upfront cystectomy, urothelial carcinoma of the bladder with variant histology
• •Adequate Organ Function per protocol definition
• •ECOG performance status ≤2
• •Received medical clearance to complete cardiopulmonary exercise testing
• •Willing to use the personal or study provided devices for monitoring and performing the exercise routines.
• •Fluent in English or Spanish for the EORTC QLQ questionnaire
• •No known contraindications to high intensity exercise