PaCO2\>8.0 kPa, or PaO2\<6.0 kPa

6-minute walking test\<160m

Obvious chronic bronchitis, bronchiectasis or other infectious lung diseases

Three hospitalizations due to pulmonary infection in the past 12 months before the baseline assessment

Previous lobectomy, LVRS or lung transplantation

LVEF\<45% and or RVSP\>50mmHg

Anticoagulant therapy that cannot be stopped before surgery

The patient has obvious immune deficiency

Participated in other lung drug studies within 30 days before this study

Pulmonary nodules requiring intervention

Any disease or condition that interferes with the completion of the initial or subsequent assessment

Evaluation of the Effectiveness of Predicting the Integrity of Interlobar Fissures Based on Chest Image AI Technology