The main questions it aims to answer are:
* Can we diagnose more people if we used 24 hour urine measurements?
* In those with high amounts of aldosterone in their urine, is there a variable pattern to their aldosterone production?
Participants will have a 24 hour urine measurement. They will also have multiple blood tests throughout the day to study the variability in aldosterone secretion.
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
People with clinically suspected PA but have not met criteria for diagnosis. Suspicion based on low-renin (renin activity \<0.5 nmol/h/L or renin mass \<5 ng/L), plasma sodium \> 140mmol/L or plasma potassium \< 4mmol/L.
Patients who have been diagnosed with PA and had previous aldosterone samples \<277 pmol/L, a level which would normally not qualify for confirmatory testing.
Patients with aldosterone results done at different times that indicate variability in production.
Willing to consent and participate in the study.
You may not be if
Inability to withdraw β-adrenoceptor antagonist therapy for 2 weeks.
People on end of life treatment.
Clareo Health | Diagnosing Variable Primary Aldosteronism.
