Second Affiliated Hospital, Zhejiang University, School of Medicine
With
Shanghai Weike Biopharmaceutical Co., Ltd.
Age
18–70
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Adenocarcinoma of colonic and peritoneal reflexive superior rectum was confirmed by pathology, aged 18-70 years;
Body condition score (PS) 0 \~ 1 in the Eastern Tumor Collaboration Group (ECOG);
Preoperative clinical stage was M1c;
No neoadjuvant therapy was performed;
Histopathologically confirmed as peritoneal metastases of colorectal cancer \> 10cm from the anus, R0-resected, adenocarcinoma/mucinous adenocarcinoma
The functions of vital organs shall meet the following requirements;
Be able to understand the situation of this study and sign informed consent.
You may not be if
Allergic history of TNF and its derivatives;
Patients with fever (\>38℃);
Active hepatitis and peripheral neuropathy (e.g., peripheral neuritis, pseudomeningitis, motor neuritis, and sensory disorders);
Pregnant or lactating women, or potentially pregnant women and sexually active men who refuse/cannot receive medically acceptable forms of contraception;
Patients with a history of malignant tumor;
Clinical symptoms or diseases of the heart that are not well controlled.
Subject has any active autoimmune disease or history of autoimmune disease (such as the following, but not limited to: interstitial pneumonia, uveitis, enteritis, hepatitis, pituitaritis, vasculitis, nephritis, hyperthyroidism, hypothyroidism;
The subject has a known history of psychotropic substance abuse, alcoholism or drug use; Subjects innate or acquired immune function defects (such as HIV infection), or active hepatitis
Other conditions in which the investigator thinks the patient should not participate in the study;
A history of neurological or psychiatric disorders, such as major depression or dementia, that may affect the informed study or follow-up evaluation;
