Gene and Protein Expression Profiles After Treatment of Actinic Keratoses

Exclusion Criteria

• •Known allergic reaction to either 5-fluorouracil , imiquimod, or melatonin
• •Immunomodulating treatment
• •Predictable poor compliance (due to i.e. dementia, substance abuse, psychiatric disease, life-threatening disease or language barriers)
• •Pregnant or breastfeeding
• •Females not in menopause (defined as no menstruation during the last 12 months) should use a secure birth control (intrauterine devices, hormonal contraceptives including - oral pills, patches, vaginal rings and injections) during the entire period of the trial