Puberty, Sex Hormones and Pain Sensitivity in Adolescents With Migraine

This study will investigate how puberty and variability in sex hormone levels impact pain sensitivity and migraine symptoms. Hypothesis 1- A significant reduction in pain sensitivity from early to late pubertal status will be found only for adolescents without but not with migraine during pubertal maturation. Hypothesis 2- Experimental pain sensitivity will be negatively correlated with testosterone levels in adolescents in both groups (with and without migraine). Exploratory Hypothesis 1- In adolescents with migraine, higher migraine severity (headache frequency and migraine disability) will be associated with lower testosterone levels. Exploratory hypothesis 2- Adolescents with migraine will have lower testosterone levels than those without.