With recorded hypertension, AND the blood pressure is not controlled (SBP ≥140mmHg and/or DBP ≥90mmHg) on 2 or more classes of anti-hypertensive drugs;
Evidence of renal artery stenosis and undergoing renal artery angiography;
Able to follow the study protocol and provide informed consent;
Renal artery angiography shows at least 1 main artery with stenosis of 50%-90%, AND the diameter is ≥ 4.0mm.
You may not be if
SBP ≥200mmHg and/or DBP ≥120mmHg at the day or randomization;
Fibromuscular dysplasia or other non-atherosclerotic renal artery stenosis;
Pregnancy or unknow pregnancy status in female of childbearing potential;
Participation in any drug or device trial during the study period;
Any stroke/TIA, OR with ≥70% stenosis of carotid artery;
Any major surgery, myocardial infarction or interventional therapy 30 days prior to study entry;
LVEF \<30%;
Comorbid condition causing life expectancy ≤1 year;
Allergy to contrast or any of the following: aspirin, clopidogrel;
Previous kidney transplant;
Previous renal artery bypass surgery or stent intervention;
Kidney size less than 8 cm measured by ultrasound;
Local lab serum Cr \>3.0 mg/dl (265.2μmol/l) on the day of randomization;
Reference vessel size \<4 mm or \>8 mm.
Clareo Health | Fractional Flow Reserve to Determine Atherosclerosis Renovascular Hypertension Stenting
