Maria A Rocca, MD

CONTACT

Paola Valsasina, MSc

CONTACT

Lead Sponsor

IRCCS San Raffaele

Collaborators

Age

18 - 65 years

Sex

ALL

Healthy Volunteers

No

•Age 18-65 years;
•Diagnosis of MS according to 2017 revised McDonald criteria;
•Ability to understand the purpose and risks of the study and provide signed informed consent;
•Ability to remotely perform VR-AOT;
•Right pre-morbid handedness (EHI\>50);
•Muscle strength deficit involving the right upper limb (≥1 point decrease of MRC scale);
•Presence of activity limitation of the right hand (need of adaptations, supervision or help by another person for the execution of daily living activities according to items 1-6 of the FIM);
•EDSS score 2.0-7.0 (inclusive);
•Cerebellar functional system score of the EDSS ≤1;
•Baseline 9HPT score \>21 seconds and \<180 seconds.

•MRI contraindications;
•Significant visual deficits not allowing to observe VR stimuli;
•Moderate to severe pain disturbances (VAS≥4);
•Concomitant neuro-psychiatric or systemic diseases (other than MS);
•Clinical relapses or steroid treatment in the past 3 months;
•Modification of symptomatic treatment or botulin toxin injection in the upper limb in the past 3 months;
•Stable disease-modifying treatment for MS for ≤6 months;
•Rehabilitation treatment in the past 3 months.