Istituto di Neuroscienze Consiglio Nazionale delle Ricerche
Age
18–65
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Age 18-65 years;
Diagnosis of MS according to 2017 revised McDonald criteria;
Ability to understand the purpose and risks of the study and provide signed informed consent;
Ability to remotely perform VR-AOT;
Right pre-morbid handedness (EHI\>50);
Muscle strength deficit involving the right upper limb (≥1 point decrease of MRC scale);
Presence of activity limitation of the right hand (need of adaptations, supervision or help by another person for the execution of daily living activities according to items 1-6 of the FIM);
EDSS score 2.0-7.0 (inclusive);
Cerebellar functional system score of the EDSS ≤1;
Baseline 9HPT score \>21 seconds and \<180 seconds.
You may not be if
MRI contraindications;
Significant visual deficits not allowing to observe VR stimuli;
Moderate to severe pain disturbances (VAS≥4);
Concomitant neuro-psychiatric or systemic diseases (other than MS);
Clinical relapses or steroid treatment in the past 3 months;
Modification of symptomatic treatment or botulin toxin injection in the upper limb in the past 3 months;
Stable disease-modifying treatment for MS for ≤6 months;
Rehabilitation treatment in the past 3 months.
Clareo Health | Home-based Action Observation Treatment With Virtual-reality for Arm Rehabilitation in People With Multiple Sclerosis
