The primary objective is to find out whether the CRS is beneficial in patients who have progressed on PARPi maintenance.
Age
18–any
Sex
FEMALE
Healthy volunteers
Not accepted
You may be eligible if
Patients with first recurrence of platinum sensitive, invasive epithelial ovarian-, fallopian tube- or primary peritoneal cancer of any initial stage.
Progression-free interval of at least 6 months after end of last platinum- containing therapy,
Progressed during PARP inhibitor maintenance
Women aged ≥ 18 years
Complete resection of the tumor seems possible (estimated by an experienced surgeon). Intra-abdominal disease has to be excluded by MRI/CT, if other surgical approaches for isolated extra-abdominal recurrences are planned
1. A positive AGO-score or iMODEL+PET/CT
2. Patients who are likely to be completely resected according to the investigator's judgment will be allowed by consensus between PI(surgeon) and designated radiologist even if AGO or iMODEL+PET/CT negative.
Patients who have given their signed and written informed consent and their consent to data transmission and -processing.
You may not be if
Patients with non-epithelial tumors as well as borderline tumors.
Patients without recurrence who are scheduled for diagnostic/second-look surgery or debulking surgery after completion of chemotherapy
More than one prior chemotherapy
Patients with second, third, or later recurrence
Patients with second malignancies who have been treated by laparotomy, as well as other neoplasms, if the treatment might interfere with the treatment of relapsed ovarian cancer or if major impact on prognosis is expected.
Patients with so-called platinum-refractory tumor, i.e. progression during chemotherapy or recurrence within 6 months after end of former first platinum- containing therapy
Only palliative surgery planned
Radiological signs suggesting metastases not accessible to surgical removal (i.e. complete resection is deemed impossible)
Any concomitant disease not allowing surgery and/or chemotherapy
Any medical history indicating excessive peri-operative risk
Any current medication inducing considerable surgical risk (e.g. bleeding: due to oral anticoagulating agents, bevacizumab)
No assessable archival tumor tissue
Clareo Health | Secondary Cytoreductive Surgery (CRS) in Patients With Relapsed Ovarian Cancer Who Have Progressed on PARP Inhibitor Maintenance
