Neural and Physiological Correlates of Psychedelic Sub-states

Inclusion Criteria

• •Have had previous experiences with psychedelic substances
• •Mentally and physically healthy
• •Have had prior experiences with MRI machines (optional but preferred)
• •Flexible schedule- able to commit to scans once or twice per week for 4 weeks in a row
• •Are between 21 and 70 years of age
• •Are fluent in speaking and reading English
• •Can swallow pills/capsules
• •If able to become pregnant, must be non-lactating, have a negative pregnancy test at study entry and prior to each Experimental Session and must agree to an adequate form of birth control and contraception over the course of the study. Adequate forms of birth control or contraception include intrauterine device (IUD), injected, implanted, intravaginal, or transdermal hormonal methods, abstinence, oral hormones plus a barrier contraception, vasectomized sole partner, or double barrier contraception. Two forms of contraception are required with any barrier method or oral hormones (i.e. condom plus diaphragm, condom or diaphragm plus spermicide, oral hormonal contraceptives plus spermicide or condom). Not of childbearing potential is defined as documented hysterectomy, bilateral salpingectomy, bilateral oophorectomy, and/or tubal ligation), permanently sterile by medical device such as Essure, postmenopausal, or male by birth. Contraception applies to males as well as females and male participants must not be planning sperm donation within the study period.
• •Able and willing to provide informed consent
• •Able and willing to use computers and tablets or phones to enter electronic data
• •Agree to inform the investigators within 48 hours of any new or changed medical conditions.