Treatment Optimisation for Blood Pressure With Single-Pill Combinations in India

Exclusion Criteria

• •1. Congestive heart failure (clinically defined).
• •2. Patients with a history of intolerance to any of the study medications for example angioedema or dry cough with Angiotensin-converting enzyme inhibitors.
• •3. Serum creatinine levels greater than 132.6µmol/l (1.5mg/dl)
• •4. 4\. History of coronary heart disease (i.e., chronic stable angina, myocardial infarction or acute coronary syndrome).
• •5. History of a stroke or other cerebrovascular accident (i.e. transient ischaemic attack or reversible ischaemic neurological deficit).
• •6. Severe hepatic impairment
• •7. Treatment with agents causing torsades de pointes
• •8. Lactation
• •9. Contraindications to any of the investigational medicinal products as per the summaries product characteristics of drugs studied
• •10. Known or suspected secondary hypertension.
• •11. Any other concomitant illness, physical or mental impairment that could interfere with the effective conduct of the study.
• •12. Pregnancy or those of child-bearing age who are not taking reliable contraception.
• •13. History of Gout.
• •14. Serum potassium \< 3.5mmol/L at screening.
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