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RECRUITINGNCT05642819

REVOLUTION Surgery (REVOLUTION Surgery)

Some people with cancer suffer from muscle wasting, lose weight and feel tired. This process, termed cachexia, is a significant problem and can lead to a reduction in both quality and quantity of life...

Lead sponsor: University of Edinburgh•1 locations•View source on ClinicalTrials.gov

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Contacts

Richard JE Skipworth, MD FRCS

CONTACT

01312423176 [email protected]

Leo R Brown, MBChB MRCS

CONTACT

01312423614 [email protected]

Sponsors

Lead Sponsor

University of Edinburgh

Collaborators

NHS Lothian

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•Patients with cancer (Clinical, histological, cytological or radiological evidence) planned for surgical resection of a malignancy of the oesophagus, stomach, pancreas, colon, or rectum
•Aged 18-years and over
•Able to give written informed consent
•Patients identified at surgical clinic as being planned for an open abdominal operation for a non-inflammatory, benign condition (e.g. donor nephrectomy)
•Aged 18-years and over
•Able to give written informed consent

Exclusion Criteria

•Any concomitant medical or psychiatric problems which, in the opinion of the investigator, would increase the risk of complication for the participant and/or investigator
•Presence of a concomitant inflammatory (e.g., rheumatoid arthritis, inflammatory bowel disease) or muscle wasting condition other than cancer
•Participants who are pregnant, suffer from claustrophobia or with implanted medical devices (e.g., cardiac pacemaker, metallic foreign bodies, aneurysm clip) would not be able to undergo the additional multiparametric magnetic resonance imaging (MRI)

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: December 2, 2025Terms

Trial snapshot

StatusRECRUITING

Phase—

Enrollment200

Start dateOct 2023

Last updatedDec 2, 2025

Condition

Cachexia Oesophageal Cancer Gastric Cancer Pancreatic Cancer Colorectal Cancer

Locations shown

University of Edinburgh

Edinburgh

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: December 2, 2025Data synced to Clareo: July 13, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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