Lead Sponsor

Fundación Española de Hematología y Hemoterapía

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

•Adult patients (over 18 years old) of both sexes.
•Patients presenting signs, assessed instrumentally or via laboratory tests, of:
•* Unexplained splenomegaly, defined as a palpable spleen ≥ 1 cm below the costal margin or diagnosed by ultrasound, magnetic resonance imaging (MRI), or computed tomography (CT) of the spleen.
•* Splenectomized patients without a diagnosis of the cause of unexplained splenomegaly.
•Patients who provide their consent to participate in the study.

•Splenomegaly due to portal hypertension (documented by abdominal ultrasound or another instrumental test) caused by liver disease
•Malignant hematologic tumor \[documented by positive physical examination + blood smear or fine-needle aspiration (FNA) or bone marrow biopsy\]
•Hemolytic anemia and/or thalassemia
•Patients unable to comply with the protocol requirements due to psychiatric and/or cognitive disorders, non-cooperative patients, or educational and written language comprehension limitations
•Patient refusal to participate in the study