The Possible Efficacy and Safety of L-carnitine and Biotin as Adjunctive Therapies in Children With Moderate Persistent Asthma

Exclusion Criteria

• •Children with any pulmonary or chronic systemic diseases other than asthma (cystic fibrosis, bronchiectasis, tuberculosis, diabetes mellitus, and liver disease).
• •Children with immunodeficiency.
• •Children with thyroid disorder.
• •Children with recent infection (especially pneumonia), surgery, anesthesia.
• •Children having clinical evidence of any heart renal and hepatic diseases.
• •Children having cystic fibrosis or congenital respiratory disease.
• •Children having chronic diarrhea and mal-absorption.
• •Children having clinical evidence of malnutrition.
• •Children on medications that could interfere with L-carnitine level including antibiotics use. (particularly ampicillins) and anti- convulsing particularly valoproic acid.