Biomarkers of Sleep-wake Cycle in Prodromal Alzheimer's Disease: Role in Cognitive Decline?

Exclusion Criteria

• •Genetic form of alzheimer's disease
• •Insufficient clinical and paraclinical information for the diagnosis of AD
• •Anticholinesterase and/or memantine treatment or on stable doses for at least 3 months
• •Use of antidepressants, anxiolytics, hypnotics, neuroleptics, 15 days before inclusion
• •Patient living in a nursing home
• •Illiteracy or inability to perform psycho-behavioural tests
• •Major physical or neurosensory problems that may interfere with the tests
• •Initial contraindication to diagnostic lumbar puncture (LP) (spinal surgery, skin infection, haemostasis abnormality, intracranial hypertension, severe coagulation disorders, curative anticoagulant therapy, severe liver failure)
• •Refusal to perform a diagnostic lumbar puncture
• •Contraindication to the use of E-Celsius: people weighing less than 40 kg, with intestinal disorders, with known swallowing disorders
• •Patient deprived of liberty, by judicial or administrative decision;
• •Major protected by law;
• •Patient in a period of relative exclusion from another protocol or for whom the maximum annual compensation of €4500 has been reached;
• •Refusal to participate in the protocol.