A Study to Evaluate the Pharmacokinetics and Safety of INCB054707 in Participants With Normal Hepatic Function and Participants With Hepatic Impairment

Exclusion Criteria

• •the opinion of the principal investigator, history of uncontrolled or unstable cardiovascular, respiratory, renal, GI, endocrine, hematopoietic, psychiatric, and/or neurological disease within 6 months of screening or evidence of rapidly deteriorating hepatic function.
• •Serum corrected calcium and phosphorus levels over the upper limits of the institutional normal ranges.
• •History or current diagnosis of uncontrolled or significant cardiac disease indicating significant risk of safety for participation in the study, including any of the following:
• •1. Recent myocardial infarction (within 6 months of check-in).
• •2. New York Heart Association Class III or IV congestive heart failure.
• •3. Unstable angina (within 6 months of check-in).
• •4. Clinically significant (symptomatic) cardiac arrhythmias (eg, sustained ventricular tachycardia, second or third degree atrioventricular block without a pacemaker).
• •5. Uncontrolled hypertension.
• •A current, functioning organ transplant or a scheduled organ transplant in the next 6 weeks from check-in.
• •History of malignancy within 5 years of screening, with the exception of cured basal cell carcinoma, squamous cell carcinoma of the skin, ductal carcinoma in situ, or Gleason 6 prostate cancer.
• •History of clinically significant GI disease or surgery (cholecystectomy and appendectomy are allowed) that could impact the absorption of study drug.
• •Severe ascites (ascites requiring paracentesis more than every 4 weeks) or an encephalopathy ≥ Grade 2 (precludes them from understanding and signing an informed consent).
• •Any major surgery within 4 weeks of screening.
• •Donation of blood to a blood bank within 4 weeks of screening (within 2 weeks for plasma only).
• •Blood transfusion within 4 weeks of check-in.
• •Current or recent history (within 30 days before screening) of a clinically significant bacterial, fungal, parasitic, or mycobacterial infection, or currently receiving systemic antibiotics or current clinically significant viral infection at screening or check-in.
• •Positive serology for HBV (eg, HBsAg) or HIV. Participants whose results are compatible with immunity due to infection or prior immunization for HBV may be included at the discretion of the investigator.