A Mass Balance Study of [14C] TAS-303 in Healthy Adult Male Subjects

Exclusion Criteria

• •1. Had current or previous hypersensitivity or allergy to drugs
• •2. Had current or previous drug abuse (including use of illicit drugs) or alcoholism
• •3. Had any concurrent disease (including symptoms and signs; however, diseases that do not affect evaluations in the study such as asymptomatic pollinosis and wart are excluded)
• •4. Received a radioisotope-labeled substance or subject to a large quantity of radiation exposure\* within 12 months before the first dose of TAS-303.
• •\* A large quantity of radiation exposure includes continuous X-ray irradiation, computed tomography (CT) scan, gastric barium test, and positron emission tomography (PET) scan, excluding tests with low radiation exposure (e.g., chest, bone, or dental X-ray examination, or X-ray examination before boarding an airplane).
• •5. Occupationally exposed to radiation within a year before the first dose of TAS-303 (such as operators who are involved in nuclear power or radiation operations).