Immune Mechanisms of Vitamin D to Reduce Chronic Pain After Burn

Exclusion Criteria

• •Substantial comorbid injury (e.g. long bone fracture)
• •Pregnancy/Breastfeeding
• •Prisoner status
• •Active psychosis, suicidal ideation, or homicidal ideation
• •Requires an emergency/bedside escharotomy or fasciotomy for the treatment of burn injury.
• •Known Child-Pugh liver disease severity classification B or C.
• •Known chronic kidney disease stage 4 or higher (GFR≤29).
• •No other history or condition that would, in the investigator's judgment, indicate that the patient would very likely be non-compliant with the study or unsuitable for the study (e.g. might interfere with the study, confound interpretation, or endanger patient).
• •Intubated and sedated at time of enrollment.
• •Hypersensitivity to Vitamin D3, ergocalciferol, calcitriol, alfacalcidol, calcipotriol
• •Known hypercalcemia (based on routine admission laboratory assessment).
• •Sarcoidosis
• •Hyperphosphatemia (based on routine admission laboratory assessment)
• •Taking Vitamin D supplements in excess of 800 IU daily.