Low-dose Bevacizumab With HSRT vs BVZ Alone for GBM at First Recurrence

Exclusion Criteria

• •Prior invasive malignancy unless disease free;
• •Received re-irradiation;
• •More than 3 relapses or evidence of subtentorial recurrent disease or tumor greater than 6 cm in maximum diameter;
• •Prior therapy with an inhibitor of vascular endothelial growth factor (VEGF) or VEGFR;
• •Pregnancy or or nursing mothers;
• •Participated in other trials after diagnosis of recurrent;
• •Influence factors toward oral medications;
• •Patients with CTCAE5.0 grade 3+ bleeding;
• •Suffering from severe cardiovascular disease: myocardial ischemia or myocardial infarction above grade II, poorly controlled arrhythmias (including men with QTc interval ≥ 450 ms, women ≥ 470 ms); according to NYHA criteria, grades III to IV Insufficient function, or cardiac color Doppler ultrasound examination indicates left ventricular ejection fraction (LVEF) \<50%;
• •Long-term unhealed wounds or fractures;
• •History of organ transplantation;
• •Serious diseases that endanger patients' safety or affect patients' completion of research,according to the researchers' judgment.