Pregnant women, breastfeeding women, women positive at Beta-HCG serology test and who hope to become pregnant

Allergy to beehive products and known allergy (general)

Cystic fibrosis

Congenital or acquired immunodeficiency syndrome and disease

History of asthma (within prior 24 months) or chronic respiratory disease

Subjects who underwent medical treatment for COVID-19 within last 3 months

History of immune system disorder or auto-immune disorder

History of treated diabetes or treated hypertension

Evidence or history of hematological, renal, endocrine, pulmonary, gastrointestinal, cardiovascular, hepatic, neurologic diseases, and malignancies

Cancers

Those considered unsuitable for the participation by the physician

No vaccination within 12 weeks prior to enrolling in the study

No antibiotics within 12 weeks prior to enrolling in the study

No anti-inflammatory drugs within 4 weeks prior to enrolling in the study

No steroids within 12 weeks prior to enrolling in the study

No immunological drugs within 4 weeks prior to enrolling in the study

No food/dietary supplements within 4 weeks prior to enrolling in the study

No current or recent participation in another clinical trial (within 30 days prior to screening)

Poplar-type Propolis Dry Extract ESIT12 : Immunomodulation Efficacy Study