Individualization of Dosage Regimens in Obese Patients: Application to Acyclovir

Exclusion Criteria

• •volunteers with nephrotoxic co-prescriptions and/or co-prescriptions that would modify the pharmacokinetics of acyclovir like diuretics, NSAIDs or statins,
• •having presented serious allergies to a drug (e.g. angioedema...), with large parenchyma insufficiencies (e.g., hepatic insufficiency, heart failure...),
• •with diabetes or taking anti-diabetics due to the possible deterioration of renal function in diabetic patients,
• •with arterial hypertension or taking antihypertensive drugs due to the possible modification of renal clearance by modification of blood flow,
• •drug interactions with acyclovir (H2 receptor antagonists (e.g., Cimetidine), Probenecid, Mycophenolate Mofetil, Lithium, Anti-calcineurins (Ciclosporin, Tacrolimus)),
• •volunteers taking anticoagulants,
• •hypersensitivity to acyclovir,
• •pregnant woman,
• •participation in another clinical study in the last two months
• •volunteers with ongoing viral HSV/VZV infection treated with acyclovir,
• •adults under guardianship or other legal protection, deprived of their liberty by judicial or administrative decision