Influence of Oxygenator Selection on Platelet Function and Rotational Thromboelastometry Following Cardiopulmonary Bypass

Exclusion Criteria

• •Pregnancy
• •Age under 18 years on the surgery date
• •Weight less than 60kg
• •Any known pre-existing bleeding disorder
• •Inability to provide informed consent
• •Pre-existing abnormal fibrinogen level (normal: 1.8-4.7g/l)
• •Significant liver disease (alanine aminotransferase or aspartate aminotransferase \> 150 U/l)
• •INR \> 1.4
• •PTT greater than 38 (off IV heparin for 12h prior to testing)
• •Direct oral anticoagulant (DOAC) use within 72h preoperatively
• •Significant renal disease (eGFR \< 50)
• •Emergency surgery
• •Intake of anti-platelet drugs (including ticagrelor and Plavix but excluding ASA) within three days (72h) preoperatively
• •Anemia (Hb \< 110)
• •Deep vein thrombosis (DVT) (within 3 months prior to OR)
• •Pulmonary embolism (within 3 months prior to OR)
• •Stroke (within 3 months prior to OR)
• •Planned hypothermia below 28 degrees Celsius.