Kinetics of cEVs Over the 24-hour Dosing Interval After Low-dose Aspirin Administration

Exclusion Criteria

• •cigarette smoking insufficiency
• •clinically significant hepatic insufficiency
• •clinically significant renal insufficiency
• •clinically significant cardiac insufficiency
• •clinically significant pulmonary insufficiency
• •history of malignant neoplasms (diagnosed and treated within the past 5 years)
• •pregnancy or lactation
• •history of malabsorption
• •regular (daily) alcohol consumption
• •regular (i.e., more than 3 days per week) non steroidal anti-inflammatory drug intake
• •type 1 diabetes excluded by islet autoantibodies evaluation (anti-glutamic acid decarboxylase, islet cell cytoplasmic, and IA-2 antibodies), family history of type 1 diabetes, age lower than 40 years, lean phenotype, early requirement for insulin therapy