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Genetics of Pulmonary Hypertension | Clinical Trials | Clareo Health

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UNKNOWNNCT05550389

Genetics of Pulmonary Hypertension

Despite the developments in recent years, pulmonary arterial hypertension (PAH) is still a disease with high mortality and morbidity. Although studies on genetic background have increased, the pathoge...

Lead sponsor: Gazi University•1 locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

Gazi University

Collaborators

ADHAD

In our study, changes in BMPR2, SARS2, KRT8, KRT18, SMAD9, CAV1, KCKN3, CPS1, TBX4, ACVRL1, G6PC3, EIF2AK4 and ENG genes will be screened in patients with PAH. In addition to previously reported changes in the relevant genes, previously unreported changes that are likely to be significant according to insilico methods are presented. Patients' age, gender, mean follow-up time, underlying congenital heart anomalies, 6-minute walk test (6 MWT), proBNP, catheter measurement values (mPAB, m RAB, Rp/Rs, PVR), vasoreactivity test positivity, World health organization functional classification (WHO-FS), cardiac function measurements by echocardiography, treatments they received will be collected retrospectively.

Age

0 - 99 years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•mPAB ≥25 mmHg, pulmonary capillary wedge pressure (PCWP) ≤15 mmHg, PVR index (PVRI) ≥3 WU.m2 in right heart catheterization.

Exclusion Criteria

•Neonatal pulmonary hypertension

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: September 22, 2022Terms

Trial snapshot

StatusUNKNOWN

Phase—

Enrollment40

Start dateJun 2021

Last updatedSep 22, 2022

Condition

Pulmonary Hypertension

Locations shown

Gazi University School of Medicine

Ankara

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: September 22, 2022Data synced to Clareo: May 25, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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