Efficacy and Safety of Remimazolam Besylate Versus Propofol for Sedation in Critically Ill Patients With Deep Sedation

Exclusion Criteria

• •Body mass index (BMI) \<18 or \>30 kg/m2;
• •Acute severe neurological disorder and any other condition interfering with RASS assessment;
• •Systolic blood pressure less than 90 mm Hg after appropriate intravenous volume replacement and continuous infusions of 2 vasopressors;
• •Heart rate less than 50 beats/min;
• •Second- or third-degree heart block in the absence of a pacemaker;
• •Unstable angina;
• •Acute myocardial infarction;
• •Left ventricular ejection fraction less than 30%;
• •Contraindicate or allergic to study drugs;
• •Moribund state;
• •Acute hepatitis or serious hepatic dysfunction (Child-Pugh class C);
• •Chronic kidney disease with glomerular filtration rate (GFR) \< 60 ml/min/1.73m2;
• •Alcohol abuse;
• •Myasthenia gravis;
• •Expected to have a general anesthesia within 8 hours;
• •Pregnancy or lactation.