Efficacy and Safety in Chinese Patients with Immunoglobulin a Nephropathy (IgAN) Who Have Completed Study Nef-301

Exclusion Criteria

• •1. Systemic diseases that may cause mesangial Immunoglobulin A (IgA) deposition.
• •2. Patients who have undergone a kidney transplant.
• •3. Patients with presence of other glomerulopathies and/or nephrotic syndrome.
• •4. Patients with acute, chronic, or latent infectious disease including hepatitis, tuberculosis (TB), human immunodeficiency virus (HIV), and chronic urinary tract infections.
• •5. Patients with liver cirrhosis, as assessed by the Investigator.
• •6. Patients with a diagnosis of type 1 or type 2 diabetes mellitus which is poorly controlled.
• •7. Patients with history of unstable angina, class III or IV congestive heart failure, and/or clinically significant arrhythmia, as judged by the Investigator.
• •8. Patients with unacceptable blood pressure control defined as a blood pressure consistently above national guidelines for proteinuric renal disease, as assessed by the Investigator.
• •9. Patients with diagnosed malignancy within the past 5 years.