the Inhaled β2-adrenergic Receptor Agonist for Transient Tachypnoea of the Newborn (the REFSAL Trial)

Exclusion Criteria

• •1. Need for intubation directly after birth or perinatal asphyxia, defined as abnormal acid-base parameters detected in an umbilical cord blood sample (pH \<7.0 or base excess \< -14 mmol/L).
• •2. Multiple apnea-brady that require immediate intubation before a trial of NIV
• •3. Age \>24 h.
• •4. Meconium aspiration syndrome.
• •5. Air leak syndrome.
• •6. Congenital heart disease.
• •7. Congenital diaphragmatic hernia.
• •8. Other severe congenital malformations and genetic disorders (diagnosed before and after birth) associated with increased risk of respiratory failure.
• •9. The need for a surfactant administration immediately after birth, regardless of the method of its administration (respiratory distress syndrome - RDS)