Minocycline for Acute Ischemic Stroke Undergoing Endovascular Treatment Due to Basilar Artery Occlusion (MIST-B)

Exclusion Criteria

• •1. Age\<18 years old.
• •2. Complete cerebellar infarct with significant mass effect or has the imaging features of acute hydrocephalus in NCCT.
• •3. Intracranial hemorrhage.
• •4. Previous stroke in the past 90 days;
• •5. cardiopulmonary resuscitation was performed within 10 days prior to onset.
• •6. Known hereditary or acquired hemorrhagic diathesis, coagulation factor deficiency, INR \>3, or platelet\<40×109/L.
• •7. Glucose \<2.2 or \>22 mmol/L.
• •8. Systolic blood pressure persistently\>185mmHg post-MT despite antihypertensive intervention; Diastolic blood pressure persistently\>110mmHg post-MT despite antihypertensive intervention.
• •9. Acute or chronic renal failure of CKD grade 3-4.
• •10. Known allergy or hypersensitivity to contrast dye or tetracycline group of drugs.
• •11. Epileptic seizure at symptom onset.
• •12. Life expectancy (except for stroke) \< 3 months.
• •13. Female who is pregnancy or breastfeeding, or whom do not use effective contraception at childbearing age.
• •14. Pre-existing mental illness that interferes with neurological evaluation.
• •15. Known current participation in another clinical investigation with experimental drug.
• •16. Unlikely to be available for 90 days follow-up.