Frailty, Outcomes, Recovery and Care Steps of Critically Ill Patients (FORECAST) Study Multi-Center Study

Inclusion Criteria

• •Must Meet both 1 and 2
• •1\. Age \> 50 years. We have selected \>50 years in keeping with prior descriptions of critically ill patients \[17\].
• •2\. Receipt of at least one of the following life support interventions for over 24 hours:
• •1. Mechanical ventilation: Both invasive and non-invasive either solely or in combination are acceptable. High flow oxygen (e.g. OPTIFLOW) as a form of Non-Invasive Ventilation (NIV) is acceptable but the patient's Fraction of Inspired Oxygen (FIO2) at the time of enrollment must be greater \> 50%.
• •2. Vasoactive medications (vasopressors or inotropes).
• •3. Acute renal replacement therapy (RRT). Patient must have been admitted to ICU for the receipt of renal replacement therapy, either intermittent or continuous and after 24 hours of ICU admission, there is a continued need for further RRT.