Circulating Tumor DNA Guided Therapeutic Strategies for CRC Patients With Small Pulmonary Nodules

Inclusion Criteria

• •1. Age ≥ 18 and ≤80 years old, regardless of gender;
• •2. Pathologically confirmed as adenocarcinoma of advanced colorectal cancer;
• •3. Lung lesions only, which was considered as metastatic by imaging consultation, and clinically diagnosed as lung metastasis of colorectal cancer;
• •4. Multiple lung lesions are allowed, but the maximum lesion diameter should be less than or equal to 2 cm;
• •5. For lesions larger than 1 cm, local treatment is planned, such as radical surgical resection or local radiotherapy, radio frequency ablation or interventional therapy (absolute alcohol treatment or cryotherapy);
• •6. Eastern Cooperative Oncology Group (ECOG) score 1 \~ 2;
• •7. The subjects (or their legal representative / Guardian) must sign the informed consent form, indicating that they understand the purpose of the study, understand the necessary procedures of the study, and are willing to participate in the study;
• •8. Surgical specimens or puncture specimens containing tumor tissue are available;
• •9. 20 mL of peripheral blood are available (10 mL per tube, two tubes in total);
• •10. Agreed to follow up for at least 2 years.