Presence of any active severe external ocular disease, inflammation, or infection of the eye and/or eyelids in either eye.

History of severe ocular trauma in either eye.

Any condition that prevents clear visualization of the fundus in either eye.

Known allergy, hypersensitivity or contraindications to any components of the study medications or other study related procedures/medications.

History of ocular surgery specifically intended to lower IOP in either eye.

History of keratorefractive surgery in either eye.

Females who are pregnant, nursing, or planning a pregnancy.

Subjects with known or suspected drug or alcohol abuse.

Participation in other investigational drugs or device clinical trials within 30 days prior to Screening.

Any decision by the Investigator to terminate a subject in screening or declare any subject ineligible for any sound medical reason.

A Comparative Confirmatory Study of STN1012600 in Subjects With Primary Open Angle Glaucoma or Ocular Hypertension