Functional Connectivity Alterations in Suicidal Patients Among Opioid Users

Inclusion Criteria

• •Each potential subject will be eligible for inclusion in this study only if the specific criteria listed below are met:
• •Be male or female aged 18-60 years old
• •Participation in H-22611;
• •Meets a World Health Organization Alcohol, Smoking and Substance Involvement Screening Test (WHO-ASSIST) score of 4+ in the opioid category;
• •Has depressive symptoms according to the Patient Health Questionnaire (PHQ)-9;
• •Has active suicidal thoughts according to Suicide Behaviors Questionnaire-Revised (SBQ-R);
• •Be able to verbalize understanding of consent form, able to provide written informed consent, and verbalize willingness to complete study procedures;
• •Female subjects must be non-nursing and not pregnant at the times of fMRI experiments and rTMS treatment;
• •Has no contraindications to MRI (pacemaker, cochlear implants, metal in eyes, other metal implants, etc.); Meets the pre-screening magnetic resonance imaging (MRI) questions provided by the Center for Advanced MR Imaging (CAMRI);
• •Has no contraindications to TMS (any types of non-removable metal in their head except the mouth, or within 12 inches of the coil, etc.).
• •Each potential subject will be eligible for inclusion in this study only if the specific criteria listed below are met:
• •Be male or female aged 18-60 years old;
• •No history of severe medical or neurological illnesses per history;
• •Be able to verbalize understanding of consent form, able to provide written informed consent, and verbalize willingness to complete study procedures;
• •Female subjects must be non-nursing and not pregnant at the time of fMRI experiments;
• •Has no contraindications to MRI (pacemaker, cochlear implants, metal in eyes, other metal implants, etc.): Meets the pre-screening MRI questions provided by the Center for Advanced MR Imaging (CAMRI);
• •Has no contraindications to TMS (any types of non-removable metal in their head except the mouth, or within 12 inches of the TMS coil, etc.).