Lead Sponsor

University of Michigan

Collaborators

Age

18 - 55 years

Sex

ALL

Healthy Volunteers

No

•Confirmed diagnosis of BD based on Diagnostic and Statistical Manual of Mental Disorders Fourth Edition (DSM-IV) criteria being met from previous enrollment in the Prechter Bipolar Longitudinal Study
•This study will select BD patients that scored above published norms (upper 50th percentile) on the NEO-PI impulsivity facet to ensure that the recruited patients exhibit the network dysfunction targeted by the tACS paradigm and therefore have the potential to benefit from this neuromodulation technique.
•Patients must be on a stable dose of medication for two weeks prior to Sessions 2 and 3.

•Significant neurological abnormalities, such as seizure disorder, mass lesions, etc.
•Known Mendelian disorder
•Active problematic substance use in the past 30 days (as determined by the Substance Use Disorder module of SCID)
•Evidence of suicidal intentions or behaviors in the past month, as judged by affirmative responses to question number 4 or number 5 on the Columbia Suicide Severity Rating Scale (CSSRS) or report of suicidal behaviors in the last 6 months
•Pregnant or trying to become pregnant, or currently lactating.