Optimal Protamine Dosing for Heparin Reversal Following Cardiopulmonary Bypass

Exclusion Criteria

• •Patients who are under 18 years of age or pregnant.
• •Patients undergoing emergency surgery (ASA class E).
• •Patients with known coagulation disorders.
• •Patients requiring circulatory arrest or deep hypothermia.
• •Patients who have not had the appropriate interruption in coumadin, direct oral anticoagulants or non-aspirin antiplatelet agents.
• •Patients on pre-operative intravenous unfractionated heparin infusions.
• •Patients ineligible for heparin administration due to known adverse reactions including allergy or heparin induced thrombocytopenia or known heparin resistance.
• •Patients who are unable to provide informed consent in the form of a signature.
• •History of adverse reaction to protamine.
• •Have any condition that, in the opinion of the investigator, will compromise the well-being of the patient or the study, or prevent the patient from meeting or performing study requirements.