Genetic Data Collection in Adult Participants to Identify Genetic Variants of Known Importance in Non-alcoholic Steatohepatitis (NASH)

Inclusion Criteria

• •One or more of the following:
• •1. A prior diagnosis of NASH with a Clinical Research Network (CRN) fibrosis score of F1 to F4 based on liver biopsy
• •2. Evidence of NAFLD by imaging or liver histology as described in the protocol
• •* The possible imaging modalities to assess historic evidence of NAFLD may be based on thresholds as described in the protocol
• •3. Known high-risk genotype for HSD17B13 (T/T or T/TA) and/or PNPLA3 (C/G,or G/G)
• •4. A clinical suspicion of NASH based on presence of 2 or more elements of the metabolic syndrome defined by:
• •1. Waistline that measures \>35 inches (89 centimeters) for women or \>40 inches (102 centimeters) for men
• •2. Historic fasting triglycerides \>150 mg/dL within the prior 6 months
• •3. Historic fasting HDL cholesterol \<40 mg/dL in men or \<50 mg/dL in women, or on cholesterol-lowering medication within the prior 6 months
• •4. Historic fasting blood glucose \>100 mg/dL or on diabetes medication within the prior 6 months
• •5. Historic blood pressure \>130/85 mmHg, or on anti-hypertensive medication within the prior 6 months