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COMPLETEDNANCT05401409

Effect of Beetroot Juice on Reducing Hypertension in Autosomal Dominant Polycystic Kidney Disease

People with autosomal dominant polycystic kidney disease (ADPKD) develop high blood pressure and kidney disease. Previous studies have shown that a commonly occurring chemical, nitric oxide (NO), is r...

Lead sponsor: Western Sydney Local Health District•2 locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

Western Sydney Local Health District

Collaborators

Westmead Institute for Medical Research

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•Diagnosis of Autosomal Dominant Polycystic Kidney Disease
•Age \> 18 years old
•Estimated Glomerular Filtration Rate (eGFR) \> 30 mL/min/1.73m2
•Treatment with at least one anti-hypertensive

Exclusion Criteria

•Inability to provide Informed Consent
•Labile, unstable, uncontrolled hypertension and/or changes in BP treatment 28 days prior to the screening visit
•Non-compliance with study procedures and/or daily BP measurements during the screening period
•Medical conditions or treatments that might interfere with the generation of NO metabolites or the primary endpoint (e.g. nitrate drugs; cigarette smoking; unwilling to stop using antiseptic mouthwash; severe, uncontrolled hypercholesterolemia; pregnancy or post-partum and lactating)
•Any serious or other medical conditions that might interfere with follow-up or stability of blood pressure (e.g. current active malignancies; uncontrolled diabetes mellitus with elevated HbA1c \> 10%)
•Dislike of taste of beetroot juice
•Allergy to beetroot
•Enrolled in other clinical trials

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: June 8, 2025Terms

Trial snapshot

StatusCOMPLETED

PhaseNA

Enrollment60

Start dateMay 2022

Last updatedJun 8, 2025

Condition

Autosomal Dominant Polycystic Kidney Hypertension Endothelial Dysfunction

Locations shown

Westmead Hospital

Sydney, New South Wales

Westmead Institute for Medical Research

Westmead, New South Wales

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: June 8, 2025Data synced to Clareo: May 25, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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