Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Janssen Research & Development, LLC
Age
18–any
Sex
MALE
Healthy volunteers
Not accepted
You may be eligible if
Diagnosed with metastatic castration-resistant prostate cancer (mCRPC)
A confirmed homologous recombination repair (HRR) gene alteration as identified by a genomic assay through use of a validated test
Eastern Cooperative Oncology Group Performance Score (ECOG PS) Grade of 0 or 1
Willing to receive concomitant prednisone/ prednisolone 10 milligrams (mg) (not provided by Janssen) daily while receiving niraparib/abiraterone acetate (Nira/AA) combination treatment
Willing to continue treatment with gonadotropin-releasing hormone (GnRH) analogue if not surgically castrated
You may not be if
Prior treatment with a Poly ADP-ribose Polymerase (PARP) inhibitor
Prior systemic therapy for mCRPC (that is, taxane-based chemotherapy, androgen signaling inhibitors). Ongoing androgen deprivation therapy (ADT), prior systemic treatment (example, apalutamide, enzalutamide, darolutamide, docetaxel) for earlier disease settings (example, hormone sensitive disease, non-metastatic castration-resistant disease); and treatment recently initiated with abiraterone acetate for mCRPC less than or equal to (\<=) 60 days is permitted
Other treatment options available or participant eligible or able to participate in a clinical trial for first line mCRPC with HRR gene alterations
Moderate-severe pain
History or current diagnosis of myelodysplastic syndrome (MDS)/acute myeloid leukemia (AML)
