R-MTX-zanbrutinib in Secondary CNS Lymphoma

Exclusion Criteria

• •Newly diagnosed DLBCL with CNS involvement
• •Previous treatment with Bruton's Tyrosine Kinase (BTK) inhibitors
• •Received targeting agents within 10 days or received chemortherapy, radiotherapy, or monoclonal antibody within 3 weeks
• •Patient has significant abnormalities on screening electrocardiogram (EKG) and active and significant cardiovascular disease such as uncontrolled or symptomatic arrhythmias, congestive heart failure, hypertension, valvular disease, pericarditis, or myocardial infarction within 6 months of screening
• •History of severe bleeding diseases
• •Patient is using warfarin or any other Coumadin-derivative anticoagulant or vitamin K antagonists. Patients must be off warfarin-derivative anticoagulants for at least seven days prior to starting the study drug. Low molecular weight heparin is allowed. Patients with congenital bleeding diathesis are excluded
• •Patient is taking a drug known to be a moderate and strong inhibitor or inducers of the P450 isoenzyme CYP3A. Participants must be off P450/CYP3A inhibitors and inducers for at least two weeks prior to starting the study drug
• •Patient is known to have human immunodeficiency virus (HIV) infection
• •Patient is known to have a history of active or chronic infection with hepatitis C virus (HCV) or hepatitis B virus (HBV) as determined by serologic tests
• •Patient is known to have an uncontrolled active systemic infection
• •Patients with serous cavity effustion
• •Patient underwent major systemic surgery ≤ 4 weeks prior to starting the trial treatment or who has not recovered from the side effects of such surgery
• •Women who are pregnant or nursing (lactating)
• •The patient is unwell or unable to participate in all required study evaluations and procedures