Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University of California, San Diego
With
University of Pennsylvania
Milken Institute
Age
18–70
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Bipolar depression (BP I and BP II) by DSM 5 criteria (Diagnostic and Statistical Manual of Mental Disorders, 2013)
Age 18-70
Right or left handed
All genders
Treatment resistant depression, as in they must have treatment resistant depression with 2 or more prior antidepressant trials that have failed to produce a response (\> 50% reduction in symptoms) using ATHF criteria (Sackeim et al., 2019)
Able to provide informed consent to participate in the study
Must be on a stable medication regimen, requiring at least one mood stabilizer
Depression severity as represented by scoring at least 20 on MADRS
Meet the safety criteria as defined in the transcranial magnetic stimulation adult safety screen (TASS).
You may not be if
No current substance abuse disorder for the past 6 months (previous substance abuse not exclusionary)
Any psychotic disorder or current active psychotic symptoms (personality disorders not exclusionary unless in the opinion of the referring psychiatrist it would jeopardize participation)
No dementia or other major neurological disorders
Not having depression as primary disorder
No major medical illness, for example metastatic cancer, end stage renal disease
Not able to verify contact information. Participants must be able to follow through with the study \& must have verified contact information and at least one verified contact
Pregnancy. While there are no known risks to a fetus this is a new use of TMS, which has not been tested, thus pregnancy is exclusionary
Score on YMRS greater than 12 (patients with mixed features have been shown not to respond well to TMS treatment (Tavares et al., 2021).
Rapid cycling Bipolar illness (patients with \> 4 mood episodes within the past year will be excluded, as they have a higher risk of switch to mania (Tondo et al., 2010)
Any implants, conditions, or contraindications that would be deemed unsafe for TMS or MRI
