Lead Sponsor

Merck Sharp & Dohme LLC

Age

18 - 75 years

Sex

ALL

Healthy Volunteers

Yes

•Has a BMI ≥18.5 and ≤35 kg/m2
•Diagnosis of chronic (\>6 months) stable Hepatic Impairment (HI) with features of cirrhosis due to any etiology (Moderate HI arm only)
•Has a score on the Child-Pugh scale ranging from 7 to 9 (Moderate HI arm only)
•In good health (except for Moderate HI)

•Anticipated survival of \<3 months (Moderate HI arm only)
•Received antiviral and/or immune modulating therapy (Moderate HI only) for Hepatitis B Virus (HBV) or Hepatitis C Virus (HCV) within 90 days prior to study start
•History of clinically significant abnormalities or diseases (Healthy matched arm only).
•History of cancer
•Major surgery and/or donated or lost 1 unit of blood
•Taking medications to treat chronic medical conditions and has not been on a stable regimen for at least 1 month (Moderate HI arm only) and/or is unable to withhold the use of the medication(s) within 4 hours prior to and 8 hours after administration of the study drug.