In Vivo PET of Synaptic Density in Cognitive Disorders

Exclusion Criteria

• •* Subject has a history of any major disease that may interfere with the investigations or make the subject unfit for participation according to the interpretation by the investigator (especially liver and kidney disease, uncontrolled diabetes or most forms of cancer).
• •* Subject has any history of a major neurological disorder or known cerebral structural abnormalities.
• •* Subject is first-degree relative (sibling, parent or children) of a person with neurological or psychiatric history assessed by a neurologist or psychiatrist (in particular dementia).
• •* Evidence of cognitive impairment as assessed by a MMSE score \< 28.
• •* Subject has a history or evidence of psychiatric disease, as assessed by a validated psychiatric symptom self-assessment tool (Symptom Checklist-90, Beck Depression Inventory (BDI) and Geriatric Depression Scale (GDS)).
• •* Subject is currently a user (including ''recreational use'') of any illicit drugs, including cannabis, or has a history of drug or alcohol abuse.
• •* Subject chronically uses medication that has central nervous system effects (e.g., opioids, neuroleptics, sedatives, anti-depressants, sleep medication).
• •* Subject has had exposure to ionizing radiation (\> 1 mSv) in other research studies within the last 12 months.
• •* Subject has a contra-indication for MRI scanning.
• •* Subject suffers from claustrophobia or cannot tolerate confinement during PET-MRI scanning procedures; subject cannot lie still for approximately 90 minutes inside the scanner.
• •* Subject is unwilling to avoid unusual, unaccustomed, or strenuous physical activity (i.e., weightlifting, running, bicycling) from the time of the pre-study visit until the end of scanning.
• •* Subject does not understand the study procedures.
• •* Subject is unwilling or unable to perform all of the study procedures or is considered unsuitable in any way by the principal investigator.
• •* Subject is pregnant (according to Ulti Med hCG urine test) or breastfeeding.
• •* Subject is a woman of childbearing potential (WOCBP) who does not agree to apply appropriate contraception methods during study participation and continues to do so for at least 6 months after study completion. For WOCBP: contraception methods with a relatively high Pearl index (natural methods, minipill outside postpartum period, spermicides or condoms in monotherapy or no usage of contraception when sexually active) are not accepted.
• •* Subject is a man with a pregnant or non-pregnant WOCBP partner, who does not agree to use a condom and continue to do so until 90 days after study completion. In addition, the non-pregnant WOCBP partner should use a highly effective method of contraception.
• •* Subject does not agree that incidental findings are communicated to the general practitioner and to the participant him/herself.
• •* Subject is on anticoagulant therapy.
• •2. Patients:
• •Subject has a history or evidence of other major neurological, major psychiatric or major internal pathology that may make him/her unfit for participation according to the interpretation by the investigator (including cardiac, lung, hematological, gastro-intestinal disorders or most forms of cancer).
• •Subject's neurological condition has a predominant impact on motor function.
• •Subject has no objective cognitive-behavioral deficit based on neuropsychological assessment.
• •Subject has important vascular changes abnormal for age or other structural lesions on MR.
• •Subject is currently a user (including ''recreational use'') of any illicit drugs, including cannabis, or has a history of drug or alcohol abuse.
• •Subject has had exposure to ionizing radiation (\> 1 mSv) in other research studies within the last 12 months.
• •Subject has a contra-indication for MRI scanning.
• •Subject suffers from claustrophobia or cannot tolerate confinement during PET-MRI scanning procedures; subject cannot lie still for 30 minutes inside the scanner.
• •Subject is unwilling to avoid unusual, unaccustomed, or strenuous physical activity (i.e., weightlifting, running, bicycling) from the time of the pre-study visit until the end of scanning.
• •Subject does not understand the study procedures or does not have a guardian who understands the study procedures.
• •Subject (or guardian) is unwilling or unable to perform all of the study procedures or is considered unsuitable in any way by the principal investigator.
• •Subject does not agree that incidental findings are communicated to the general practitioner and to the participant him/herself.
• •Subject is pregnant (according to Ulti Med hCG urine test) or breastfeeding.
• •Subject is a woman of childbearing potential (WOCBP) who does not agree to apply appropriate contraception methods during study participation and continues to do so for at least 6 months after study completion. For WOCBP: contraception methods with a relatively high Pearl index (natural methods, minipill outside postpartum period, spermicides or condoms in monotherapy or no usage of contraception when sexually active) are not accepted.
• •Subject is a man with a pregnant or non-pregnant WOCBP partner, who does not agree to use a condom and continue to do so until 90 days after study completion. In addition, the non-pregnant WOCBP partner should use a highly effective method of contraception.