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Role of miRNAs in CVD and Periodontitis | Clinical Trials | Clareo Health

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COMPLETEDNCT05383794

Role of miRNAs in CVD and Periodontitis

Several micro-RNA plays a key role in endothelial function and may be a link for the known interaction of periodontitis and cardiovascular disease. The investigators compared the impact of gingival he...

Lead sponsor: University of Catania•1 locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

University of Catania

The investigators compared the impact of gingival health, periodontitis (CP), cardiovascular disease or of both diseases (CP +cardiovascular disease) on gingival crevicular fluid miRNA 7a-5p, miRNA 21-3p, miRNA 21-5p, miRNA 200b-3p, miRNA 200b-5p, miRNA 100-5p, miRNA 125-5p levels.

Age

All ages

Sex

All

Healthy Volunteers

No

Inclusion Criteria

•Presence of at least 15 teeth
•CP with a minimum of 40% of sites with a clinical attachment level (CAL)
•≥2mm and probing depth (PD) ≥4mm;
•Presence of at least ≥2 mm of crestal alveolar bone loss verified on digital periapical radiographs
•Presence of ≥40% sites with bleeding on probing (BOP)

Exclusion Criteria

•Intake of contraceptives
•Intake of immunosuppressive or anti-inflammatory drugs throughout the last three months prior to the study
•Status of pregnancy or lactation
•Previous history of excessive drinking
•Allergy to local anaesthetic
•Intake of drugs that may potentially determine gingival hyperplasia such as Hydantoin, Nifedipine, Cyclosporin A or similar drugs.

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: May 20, 2022Terms

Trial snapshot

StatusCOMPLETED

Phase—

Enrollment115

Start dateApr 2019

Last updatedMay 20, 2022

Condition

Cardiovascular Diseases Periodontal Diseases

Locations shown

University of Catania

Catania, CT

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: May 20, 2022Data synced to Clareo: June 28, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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