Nicotine Pharmacokinetics Following Use of the P4M3 Gen 2.0 E-Cigarette Compared to Smoking Cigarettes

Exclusion Criteria

• •As per the Investigator's judgment, the subject cannot participate in the study for any reason other than medical.
• •Subject has donated or received whole blood or blood products within 30 days prior to Screening Visit.
• •BMI \< 18.5 kg/m2 or \> 35.0 kg/m2.
• •Subject has received medication within 14 days or within 5 half-lives of the drug prior to Admission (whichever is longer), which has an impact on CYP2A6 activity.
• •Subject has a positive serology test for HIV 1/2, Hepatitis B or Hepatitis C.
• •Subject has a history of alcohol abuse that could interfere with the subject's participation in study.
• •Subject has a positive urine drug test.
• •Subject has a positive alcohol breath test.
• •Subject has participated in another clinical study within 30 days prior to the Screening Visit.
• •Subject is pregnant (does not have negative pregnancy tests at Screening Visit and at Admission) or is breastfeeding.
• •For women of childbearing potential only: subject does not agree to use an acceptable method of effective contraception.