Mariangela Pellegrini, MD, PhD

CONTACT

Lead Sponsor

Uppsala University

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

•Neurosurgical patients on mechanical ventilation and with ongoing intracerebral pressure monitoring will be included in the study
•Age \>18 years;
•MV expected for more than 72 hours;
•Not pregnant;
•Informed consent from patient or next of kin.

•Previously demonstrated paralysis of the diaphragm or know pathology of the phrenic nerve or neuromuscular disorder;
•Chest tube;
•Patients with clinical conditions that contraindicate the insertion of esophageal/gastric catheters (e.g., esophagus rupture, esophageal bleeding);
•Pacemaker and/or implantable cardioverter defibrillator, these last being a contraindication for EIT;
•Hemicraniectomy. In case of late hemicraniectomy (after patient inclusion), the patient will drop-out from the study.
•Relative contraindication: in case of skull base fracture the patient can be included only if oesophageal/gastric and NAVA catheters can be inserted orally.