VL-3 Training Study

Exclusion Criteria

• •1\. Pregnant and/or breastfeeding. 2. Presence of a condition or abnormality that in the opinion of the Investigator would compromise the safety of the patient or the quality of the data.
• •3\. Are unable or unwilling to undergo all assessments associated with the study.
• •4\. Have a history of poor quality or difficulty performing auscultation measurements.
• •5\. Subjects shall be excluded if the Korotkoff sound \[fifth phase (K5)\] is not audible 6. Subjects with vascular implants in the arm of measurement, such as those used for dialysis 7. Subject suffering from a medical condition prohibiting blood flow occlusion in either arms.
• •8\. Pre-existing conditions that may interfere with the accuracy or interpretation of auscultatory readings, such as aortic coarctation, arterial-venous malformation, occlusive arterial disease, or the presence of an antecubital bruit.
• •9\. Subjects who have known allergies to nitroglycerin (for subjects undergoing the nitroglycerin challenge).
• •10\. Subjects who have taken short acting nitroglycerin within 4 hours of the scheduled study. Such studies will be deferred for at least 4 hours.
• •11\. Subjects who have taken long acting nitroglycerin within 8 hours of the scheduled study. Such studies will be deferred for at least 8 hours.
• •12\. Subjects with pericardial tamponade, restrictive cardiomyopathy, or constrictive pericarditis, or cardiac output is dependent upon venous return