About Pricing FAQs Blog

Loading clinical trials...

Your health journey, clearly organized.

Find Clinical Trials →

Legal

Privacy Policy
Terms of Service

© 2026 Clareo Health. All rights reserved.

THRIVE Feasibility Trial | Clinical Trials | Clareo Health

Back to clinical trial search

COMPLETEDPhase 3NCT05346588

THRIVE Feasibility Trial

To evaluate the feasibility of a pragmatic, large scale, comparative effectiveness, randomized evaluation of patient experience of intravenous propofol versus inhaled volatile anesthesia.

Lead sponsor: Washington University School of Medicine•4 U.S. locations•View source on ClinicalTrials.gov

Clareo plain-language summary

What this study is about

Generating AI summary...

Save this trial guide to your notes

Keep your clinical trial research organized — questions to ask, what to expect, and key details.

Sponsors

Lead Sponsor

Washington University School of Medicine

Collaborators

University of Michigan
University of Pennsylvania
Stanford University
Patient-Centered Outcomes Research Institute

Two-center single-blinded randomized feasibility study, with randomization 1:1 to either propofol TIVA or inhaled volatile general anesthesia for patients who are receiving elective non-cardiac surgery. Patients will be stratified by clinical site with 150 participants per site.

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•18 years or older
•Undergoing elective non-cardiac surgery expected to last ≥ 60 min requiring general anesthesia, including a tracheal tube or laryngeal mask airway (or similar supra-glottic device)

Exclusion Criteria

•Inability to provide informed consent in English
•Pregnancy (based on patient report or positive test on the day of surgery)
•Surgical procedure requiring general, regional, neuraxial anesthesia administered by an anesthesia clinician (anesthesiologist, CRNA, anesthesiology assistant) occurring within 30 days prior to or planned to occur within 30 days after surgery date
•Contraindication to propofol TIVA or inhaled volatile (for example, documented allergy to propofol, history of severe postoperative nausea or vomiting, concern for or history of malignant hyperthermia)
•Surgical procedures requiring specific general anesthesia option (for example, TIVA required for neuromonitoring).
•Hospital approved, written protocol mandating a particular technique
•History of intraoperative awareness during general anesthesia based on patient self-report on the day of consent
•Planned postoperative intubation

Related studies

Complications Related to the Anaesthesia During Airway Endoscopy in Children With Tracheostomy.

NCT06906263 · Anesthesia Complication, Tracheostomy Complications, and more

Vascular Events In Patients Undergoing Same-day Noncardiac Surgery (VALIANCE) Study

NCT04973397 · Preoperative Care, Surgery--Complications, and more

RECRUITINGEARLY Phase 1

Zinc Oxide Versus Petrolatum Following Skin Surgery

NCT03561376 · Surgical Incision, Surgery--Complications, and more

Trajectories of Recovery After Intravenous Propofol Versus Inhaled VolatilE Anesthesia Trial

NCT05991453 · Surgery-Complications, Anesthesia Complication, and more

Preoperative Blood Volume Optimization Using Transthoracic Echocardiography

NCT06639737 · Anesthesia, Anesthesia Complication, and more

View all related studies →

Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: November 24, 2023Terms

Trial snapshot

StatusCOMPLETED

PhasePHASE3

Enrollment300

Start dateSep 2022

Last updatedNov 24, 2023

Condition

Surgery--Complications Anesthesia Complication Anesthesia Awareness Anesthesia Emergence Delirium Anesthesia+7 more

Locations shown

Stanford University

Stanford, California

University of Michigan

Ann Arbor, Michigan

Washington University School of Medicine

St Louis, Missouri

For caregivers

Use Clareo to keep notes, questions, trial details, and next steps organized before and after appointments.

Start free trial →

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: November 24, 2023Data synced to Clareo: May 25, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions