Use of GnRHa During Chemotherapy for Fertility Protection

Exclusion Criteria

• •Demonstrated premature ovarian failure at time of randomization according to clinical or biochemical data
• •Previous or planned bilateral oophorectomy
• •Pregnancy or breastfeeding at time of start of chemotherapy
• •Other malignancy diagnosed within the last five years
• •Uncontrolled hypertension, heart, liver, kidney related or other uncontrolled medical or psychiatric disorders including previous or current diagnosis of anorexia
• •Known osteoporosis
• •Known low platelet count with increased bleeding risk or refractory thrombocytopenia in subjects with acute leukemias
• •Known or suspected allergy against triptorelin
• •Direct radiation of the gonads previous or planned (TBI allowed)
• •Mental inability, reluctance or language difficulties that result in difficulty understanding the meaning of study participation